H2 blockers and proton pump inhibitors are GERD medications which decrease the amount of stomach acid produced and released. As mentioned on my other pages on this subject, conventional help for GERD focuses on control of stomach acid.
Drugs in the H2 category, such as Zantac (Ranitidine HCl), Tagamet (cimetidine), Axid (nizatidine) and Pepcid (famotidine), work by stopping the production of histamine.
They are also called histamine type-2 receptor antagonists (H2RAs). These medications can provide relief in 30 minutes and last up to 12 hours in some cases.
You probably have heard about antihistamines like Benadryl to combat allergic reactions and wonder how histamine can be involved in GERD. Allergic reactions are not the only use of histamine.
Depending on the receptor, H1 through H4, histamine can bind to on different cells and thus have desirable and undesirable consequences. A few other examples where histamine may be involved are in:
In the stomach, histamine stimulates acid-producing cells to produce stomach acid.
H2 blockers are meant to be used short-term (less than 2 weeks) unless prescribed by a physician. Minor side effects according to www.medicinenet.com and other sources include:
Although rare, major side effects include: agitation, anemia, confusion, depression, easy bruising or bleeding, hallucinations, hair loss, irregular heartbeat, rash, visual changes, and yellowing of the skin or eyes.
They also interfere with the body’s ability to use drugs that require acid for proper absorption, and they can interfere with absorption and/or excretion of nutrients like chromium.
One thing that is lesser known is that H2 Blockers are shown to disrupt gut microbiota. A 2013 study in premature infants showed that microbial diversity was lower and relative abundance of Proteobacteria (a phylum comprised of many Gram-negative pathogens) was increased in the stools of infants receiving H2-blockers compared with those who had never received them. The authors of the study suggested that the use of H2 blockers in premature infants may predispose the vulnerable immature gut to necrotizing enterocolitis, a very serious and dangerous infection of the intestines.
Let’s look at ingredients in these three histamine-2 blockers. Always read the product information sheets! At the time of this writing:
Zantac – Comes in 3 varieties with strengths of 75 mg or 150 mg rantidine per tablet to be swallowed. Some questionable ingredients may be a synthetic red iron oxide, triacetin [a chemical commonly used as a cosmetic biocide (literally means life-killer!) plasticizer and solvent in cosmetics (makeup, etc.)], artificial color, artificial sweetener, and synthetic preservative.
Tagamet HB 200 – Questionable ingredients are cornstarch (probably GMO), preservative, sodium lauryl sulfate. As Snopes.com says regarding sodium lauryl sulfate in personal care products, it “is an irritant…and you really don’t want to swallow the stuff.”
Pepcid – Comes in 3 product varieties: 2 are Pepcid AC in tablet form with just famotidine as the active ingredient with starch (GMO?) and talc as the main questionable ingredients; and 1 is Pepcid Complete with the antacids calcium carbonate and magnesium hydroxide and the H2 blocker famotidine as the active ingredients with cornstarch (probably GMO), corn syrup solids, dextrose, artificial colors and flavors, maltodextrin, mineral oil, artificial sweeteners and triacetin (see Zantac, above) as possible inactive ingredients.
Note that each flavor of Pepcid Complete contains lactose as an inactive ingredient.
You can see that histamine-2 blockers are not the answer for a cure for GERD, since they are meant to be used for less 2 weeks and they have some undesirable side effects and ingredients. Instead, see which diet and lifestyle changes you can make to try to eliminate the cause of frequent reflux and heartburn.
Check out these other pages:
I research studies and share my clinical experience to write this free site to help you find solutions to your problems. As part of that, I recommend products and services that I genuinely believe will be of help to you. If you click on a link to a product/service, I may receive a small commission if you buy something. The item does not cost you more.
Thanks for visiting this site! If you've enjoyed reading this page or have found the information to be useful to you, please "like", tweet about it, or share it so others can benefit, too. You can leave comments below via Facebook or Disqus.
Comment with Disqus (including as a guest), Twitter or Google accounts:
If you are one of my many readers without a Facebook account, you can still comment.
Disclaimer: Please note: By law, I cannot provide any personalized recommendations for your specific health concern on this site. The information contained in this site is educational in nature and is not intended as diagnosis, treatment, prescription or cure for any physical or mental disease, nor is it intended as a substitute for regular medical care. Consult with your doctor regarding any health or medical concerns you may have.
Subscribe to my monthly newsletter and receive a free copy of "The Quickstart Guide to Probiotics."
To comply with the EU's GDPR data privacy regulation, please subscribe here:
Some competitors of SBI (Solo Build It) are posting fake negative reviews of SBI. If you are considering creating your own website business, or if you have a brick-and-mortar business but want an online presence, I highly recommend SBI!