Hyperbiotics PRO-15: “The Perfect Probiotic” Supplement?
Hyperbiotics PRO-15 is a multi-species probiotic supplement in tablet form. It is marketed as “The Perfect Probiotic” for “seeking to promote the balance of beneficial flora on a daily basis or you’re looking to repopulate your probiotic colonies.” It is one of seven products in the Hyperbiotics line.
It is also marketed to be 15 times more effective than vegetarian capsules, but what are the details of those claims?
What Probiotic Strains are in Hyperbiotics PRO-15?
Hyperbiotics PRO-15 probiotic supplement contains 15 lactic acid bacteria for a total of 5 billion CFU per tablet:
These beneficial bacteria are supplied by Nutraceutix and produced into tablet form using Nutraceutix’s patented LiveBac® and BIO-tract® technologies (discussed below).
What are the Other Ingredients in Hyperbiotics PRO-15?
The other ingredients at the time of this writing are microcrystalline cellulose, hydroxypropylmethlycellulose, pectin, stearic acid, sodium carbonate, guar gum and turmeric. The stearic acid is a flow agent to make the tablets glide over equipment easier. The sodium carbonate is used to control the pH inside the tablet and around the disintegrating tablet in your intestine. The other ingredients in Hyperbiotics PRO-15 make up the time-release aspects of the tablet.
Please verify ingredients of any supplement prior to taking it.
What is the Recommended Dosage of Hyperbiotics PRO-15 and for which conditions or claims?
For daily maintenance, 1 tablet per day prior to food is recommended by the manufacturer.
For intense therapy, such as after a course of antibiotics, 3 tablets once per day prior to food is recommended by the manufacturer.
What are the Pros of Hyperbiotics PRO-15?
The pros of this probiotic supplement as I see them are:
It contains 15 different species of lactic acid bacteria.
The probiotic strains are identity-verified from ATCC culture collections and grown and harvested in Washington State in the US in Nutraceutix’s facility.
The tablet is a pea-sized pearl to make it easier to swallow than large capsules (although it may have a rough edge where the tablet is compressed together.)
It is vegetarian.
It contains NO GMO’s, yeast, lactose, soy, iron, gluten, wheat, nuts, chemicals, preservatives, sugar or artificial colors or flavors.
It is shelf-stable, and reportedly there will still be viable bacteria (albeit in unknown amounts) at the end of 18 months.
Hyperbiotics PRO-15 is produced by Nutraceutix in a GMP (Good Manufacturing Practices) facility in the US. It appears that Nutraceutix handles the growth,
manufacturing and packing of all materials and Hyperbiotics merely sells
the final products.
When questioned, the company says that Hyperbiotics PRO-15 is kosher.
The probiotics are manufactured into tablet form using Nutraceutix’s
patented LiveBac® and BIO-Tract® processes. The LiveBac® process
utilized nitrogen to quickly cool the tablets to reduce microbe loss
from the heat experienced during the tablet-making process. The
BIO-Tract® process uses time-release technology with the combination of
hydrophilic (water-attracting) agents and pH control agents. Once the
tablet encounters liquids in your stomach, it begins a slow breakdown
process. Based on laboratory-simulated digestive conditions, the
BIO-Tract® process is reported by Nutraceutix to deliver 60% of live,
viable bacteria to the intestines instead of the alleged 4% for plain
vegetarian capsules with no microbe encapsulation. Note that a
digestion model was used and that your results may be different. Additionally, I have some questions about how the study was conducted and will update this page once/if I receive that information.
the bacteria in tablet form reduces their exposure to air and moisture.
Nutraceutix uses this technology for other supplements, too.
Hyperbiotics says that they test for an array of items including physical analysis, potency, culture identity, ingredient identity and the presence of allergens, metals and other contaminants.
Here is a picture from the Hyperbiotics website that shows the BIO-Tract delivery:
This product has many good, verified-purchase reviews on Amazon.com, averaging 4.5 stars for over 2900 customer reviews as of the time of this writing. Some of the reviews state:
“No more stomach grumbles or digestive noises. This product just made my digestive system a non issue.” – October 29, 2015
“Since using this probiotic, I've noticed a big difference in my gut health. At first, I didn't notice much of a change and, frankly, thought this wasn't worth my time or money. So, I stopped taking it. Very quickly after stopping, my GI tract became erratic and irritable. I, also, began to get sick frequently. I went out on a limb, bought another bottle, and within around a week things began to settle and line out. I'm a fan and have referred several of my friends/family to this probiotic.” October 27, 2015
“I was extremely surprised after trying this at how well it got rid of the bloating I was experiencing in mornings. I usually take one every other day because I'm afraid of becoming too dependent on it. It's really gentle on the stomach and doesn't need to be taken with food. I'd recommend this to anyone.” – October 8, 2015
“Severely helped my IBS / Colitis symptoms. I take 2 pills a day every day, and this has saved me from having to go back to the doctor to get another colonoscopy. If you have IBS or Ulcertive Colitis, give this stuff a try before going on medicine with crazy side effect. You have very little to lose, but so much to gain.” – October 1, 2015
What are the Cons of Hyperbiotics PRO-15?
Of course, there are some unfavorable reviews of Hyperbiotics PRO-15, too.
the entire bottle as directed, sometimes taking double doses as
suggested if not seeing results. Feel the same. Either it does not work
or I have a different situation. Not a miracle cure by any means
however." - March 9, 2015
used probiotics off and on for many years to soothe my digestive system
and ward off yeast infections. I gave this product a couple of weeks to
kick in, but taking PRO-15 was as if I was not taking probiotics at
all. I purchased it because of the great reviews and was, frankly,
disappointed. Maybe it's just me, but I'm inclined to conclude
otherwise. There are plenty of other probiotics I've taken with
significantly better results within a day or two." - November 6, 2014
have been using this for a month and have not noticed any change. I
have IBS-A and was hoping this would help my symptoms. Nothing has
changed though, doesn't seem to affect me." - January 15, 2015
took these religiously for the entire bottle and they didn't seem to do
anything, I even took up to 3 at a time and still didn't help with my
stomach issues." - February 6, 2015
The cons of this probiotic supplement as I see them are:
the species are given; you don't know which strains are in the product
since the information is proprietary.
Here is what Hyperbiotics said
when questioned on Amazon about the strains in the product: “Here is an overview of our favorite 8…
fermentum - Identified as highly antimicrobial and antioxidative. Helps
inhibit the growth of harmful bacteria, yeast and other pathogens and
has demonstrated clinical efficacy within immune health.
acidophilus - Creates a fortress of good colonies that helps keep
unwanted organisms out of your gut. Studies show that L. acidophilus
helps to reduce occasional diarrhea and enhances your immune system and
may help to reduce cholesterol levels. Studies have shown that those
taking L. acidophilus experienced significantly more relief from their
gastrointestinal discomfort than did those taking a placebo.
casei - Along with L. Acidolphilus, converts lactose into lactic acid,
helping those who are lactose intolerant. Helps to encourage the growth
of other beneficial bacteria.
B. longum - Assists in
breaking down carbohydrates and fighting free radicals. Provides potent
antioxidant support and helps to reduce the effects of seasonal
allergens. When questioned, Hyperbiotics said that the strain is Bl-05.
B. lactis - Helps decrease H. pylori and helps the production of the front line cells in your immune system.
L. rhamnosus - The leading defense for travelers. Helps reduce occurrences of traveler's diarrhea and food poisoning.
plantarum - Secretes the oxidant hydrogen peroxide which acts as a
weapon to protect your body and must be present for your immune system
to function correctly. Creates a healthy barrier in your colon and helps
lower luminal pH, creating an unfavorable environment for the growth of
pathogens including molds, yeasts and bacteria.
Infantis - Has been shown to reduce the major symptoms of
gastrointestinal disorders, including diarrhea, flatulence, bloating,
cramping and constipation. It is particularly popular as a means of
combating Irritable Bowel Syndrome (IBS) and has been shown to improve
digestion and the body's ability to absorb and process nutrients.”
They also said, “While many of our probiotic strains do not have identifier numbers, (meaning strain identification)
they are the identical genus and species as strains that do contain
identifier numbers but without the high price tag that results from
usage in clinical trials and the marketing costs associated with that.” So
in other words, the strains are not ones used in clinical trials, and
the information they provided about the different species may or may not
relate to the strains used in the product.
total CFU is given; you don't know how much of each species is present.
Here is what Hyperbiotics said when questioned about this: “PRO-15 has
an approximately even split between the 15 strains…” so that would mean that each strain is present in about 0.3 billion CFU.
total CFU is at the time of manufacture, not at expiration, so you
don't know if you are really getting the amount listed on the label by
the time you finish the bottle. However, stability studies at room
temperature on 3 different lots of the products showed that after 18
months approximately 55% of the microbes were still viable. Hyperbiotics
told me that by 18 months after the date of manufacture, their formulas
contain about 40% of the initial CFU count. They are in the process of
updating all of their labels to list the guaranteed dose at time of
expiration (November, 2015).
Since neither the strains nor
the amounts of each strain are listed, it is not possible to predict
what effects on promoting the balance of beneficial flora on a daily
basis or repopulating your probiotic colonies this product will have.
This supplement may contain trace amounts of the milk protein casein. Allergy alert!
Hyperbiotics PRO-15 also contains FOS, a carbohydrate prebiotic to support the
growth of the microbes, which may pose problems for some people even
though it is at a small amount of 25 mg per tablet.
As with most
probiotic supplements, this one should be kept below 70 degrees F which
usually translates into refrigeration after it is delivered.
studies with this supplement as a whole supplement have been performed
to my knowledge. Note that this is not unusual, however. Very few
multi-species probiotic supplements are used in studies. Instead,
species and strains that are show to be effective are mixed together in
most multi-species supplements such as this one. Whether or not the
strains compete with each other in a laboratory setting is not known
since we don’t know which strains are in it.
Compared to other
multi-species probiotic supplements, this one contains a lower number of
total CFU of 5 billion per capsule. Assuming it delivers 15 times more
probiotics to the intestines than
plain vegetarian non-encapsulated supplements as the in vitro simulated
digestive system tests showed, Hyperbiotics says that their 5 billion
correlates to 75 billion CFU of other products. However, it is still a
low number of CFU and many probiotic supplements on the market either
have encapsulation to protect the beneficial bacteria or utilize strains
that survive passage to the intestines.
Sold only online.
be fair, Hyperbiotics said that they are running new studies on their
entire line as of November, 2015, and will update me on the results. I
will update this webpage if/when I receive a reply.
Where to Find Hyperbiotics PRO-15?
Hyperbiotics sells each of their products on their website, but they also sell them via their online stores in the Amazon Marketplace in the US, in Canada and in the UK.
Is Hyperbiotics PRO-15 the Right Supplement for YOU?
Without me knowing your health history, only you can decide if this probiotic supplement is right for you. Although it has mostly good reviews, 10% of customer reviews on Amazon.com were for one or two stars, so it doesn’t work for everyone. But then, what does?
Hyperbiotics PRO-15 has "safe" species of Lactobacillus, Bifidobacterium and Streptococcus, has a nice delivery system, has shelf-stability in transit and is free of most allergens. It also does not use plasticizers to protect the microbes. Nonetheless, I personally would not consider this supplement “The Perfect Probiotic”.
Thanks to Jany and Jean for suggesting a review of this supplement!
One Other Note
If you decide to take Hyperbiotics PRO-15, I would combine the health benefits of it with the benefits provided by:
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