Probiotic Pearls Adult 50 Plus Probiotic Supplement are Gems

Probiotic Pearls Adult 50 Plus are an all-Bifidobacterium probiotic supplement manufactured by Enzymatic Therapy, Inc. Some boxes may show Nature's Way as the company, but the Nature's Way website is not listing this product as their own. Both Enzymatic Therapy and Nature's Way are part of the Schwabe Group and both share the same headquarters in Green Bay, Wisconsin, USA.

This probiotic supplement is marketed for digestive and colon support. It is also marketed to:

  • Protect against occasional gas, bloating and constipation
  • Maintain regularity and digestive balance
  • Support immunity and colon health

This supplement is also said to have an advanced triple-layer softgel that protects the microbes from heat, air, moisture and stomach acid to maximize survival and delivery to the intestine. 

Which Probiotic Strains are in Probiotic Pearls Adult 50 Plus?

Each gel pearl contains 1 billion CFU of a proprietary blend of 5 Bifidobacterium species:

  1. Bifidobacterium longum BB536
  2. Bifidobacterium breve M-16V
  3. Bifidobacterium lactis Bl-04
  4. Bifidobacterium infantis M-63
  5. Bifidobacterium bifidum Bb-02

What Are the Other Ingredients in Probiotic Pearls Adult 50 Plus?

The other ingredients at the time of this writing (August, 2018) are: vegetable oil (palm, coconut), fish gelatin (tilapia), vegetable glycerin, soy lecithin, pectin, and silicon dioxide. It is a product of Japan.

This softgel appears to be very similar to the Nature's Way Probifia Pearls which were made in Japan and are no longer distributed by Nature's Way.

Please always verify ingredients of any supplement before taking it!

What is the Recommended Dosage of Probiotic Pearls Adult 50 Plus?

The recommended dosage is one softgel daily that may be taken with or without food. However, you must not chew or crush the pearl or the probiotic's protection will be inactivated.

What are the Pros of Probiotic Pearls Adult 50 Plus?

The pros of this probiotic supplement as I see them are:

  • There are not many Bifidobacterium-only probiotic supplements available on the market and this one has specific and well-known, documented strains in it.
  • The triple-layer softgel pearl is a unique delivery method that may provide better delivery. In the digestive tract, most Bifidobacterium reside in the colon. Bifidos are more sensitive to stomach acid and bile than other probiotic genera, so protecting them until they reach their determined target may mean that less bacteria are needed to achieve results of higher-strength ones.
  • Free from gluten, preservatives, salt, sugar, wheat, artificial coloring, and artificial flavoring
  • Shelf-stable. No refrigeration is required, but it’s always a good idea to refrigerate probiotics, unless the label specifically says not to.
  • Enzymatic Therapy is an FDA-registered drug facility (USP) which means that it meets higher standards than non-drug facilities. This facility is able to perform stability and bioavailable testing to ensure the product maintains its potency throughout its shelf life and releases its bacteria in the body.
  • Individually blister-packed


Some positive, verified-purchase Amazon.com reviews:

"Helps relieves my IBS symptoms. Stomach doesn't cramp or hurt anymore. Finally, I found a great product to get rid of GI problems." – August 10, 2016   

"These pearls have worked great for my husband. He has been having intestinal problems, so I bought these for him, and they have helped tremendously. This is actually my second package of these - they work great!" – December 14, 2017

"I bought these for my Mom, who had colo-rectal cancer. She really loves them. She used to use the bathroom numerous times per day, but after taking these for a couple of weeks, her system has regulated. And, she's not a healthy eater. So these must be doing the trick. I'm buying two more packs today, one for her and one for me! Thank you for making a great product. I love that they're easy to swallow, too." – January 26, 2018

What Are the Cons of Probiotic Pearls Adult 50 Plus?

The cons of this probiotic supplement as I see them are:

Allergy alerts! The pearls contain fish and milk proteins as well as soy, coconut oil and palm fruit oil. According to the Enzymatic Therapy website, lecithin may contain trace levels of soy proteins but not enough "to provoke allergic reactions in the majority of soy-allergic consumers." The questions I would ask myself if I were allergic to soy are:  Am I in the majority or the minority? Am I willing to test it or can I find something else instead?
This is a low-potency probiotic supplement. However, if the strains are delivered to the colon intact, this supplement may outperform higher-potency products with Bifidobacterium in them.
No studies with this supplement as a whole supplement have been performed to my knowledge. This is not unusual, however. Very few multi-species probiotic supplements are used in studies. Instead, species and strains that are show to be effective are mixed together in most multi-species supplements such as this one.

Some negative or neutral, verified purchase Amazon.com reviews are listed below. There were not many available.

"Tried this for 2 months, started taking 2 a day, then 3 a day, still not working that well." – December 9, 2017

"I have been taking these for three months now and honestly I feel the same. I have IBM and thought maybe these would help. Maybe they have a little. I'm thinking of stopping them for a couple of months and see if I can tell the difference." – June 6, 2017

"Can't really tell if a probiotic works for me or not and I've purchased many brands ranging in price. All of them, except Pearls, had to be refrigerated, which was always a problem in shipping. It does, however, reduce the amount of times I reach for an antacid." - May 7, 2015

Where Can You Find Probiotic Pearls Adult 50 Plus?

You can find this probiotic supplement through my dispensary at Fullscript. You may also be able to find it at:

Is Probiotic Pearls Adult 50 Plus the Right Supplement for You?

As I mentioned, there are very few 100% Bifidobacterium probiotic supplements on the market today. If the allergies are of no concern to you, this is a good, albeit low strength, Bifidobacterium supplement. It is similar to the discontinued Probifia Pearls supplement, but has one extra bifido.

There are also different formulation of the pearls with the same delivery method. Check out the dispensary for the Women’s, Acidophilus, Complete, Immune, and Elite formulas.


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