Renadyl (ren’-a-dill) is a probiotic supplement manufactured by Kibow Biotech in Pennsylvania. Kibow Biotech was founded in 1997 and specializes in the development and commercialization of scientifically-formulated and clinically-tested probiotic and prebiotic dietary supplements, primarily in the management of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in human and veterinary applications. Kibow holds the registered trademark for the term “Enteric Dialysis", which means using the colon as a way to filter blood.”
Renadyl is proven to help people with chronic kidney disease by alleviating the burden of toxic waste products which are damaging to the kidneys and the serious side effects of toxic waste buildup in the bloodstream. The probiotics in this supplement have been shown to use nitrogenous wastes such as urea, uric acid, creatinine, indoles, phenols, and nitrosamines and their precursors for their growth in the colon. By growing, the probiotics can multiply and become more efficient at reducing wastes. These wastes and others naturally diffuse from the bloodstream into the bowel, and reduction of those compounds in the bowel results in reduction of the total toxic waste burden on the kidneys. The by-products of the wastes metabolized by the probiotic microbes are eliminated in feces.
The former name of this probiotic supplement was “Kibow Biotics”.
For more information on caring for chronic kidney disease, including the use of probiotics, see this page.
For information on how CKD is assessed, risk factors and early symptoms, see this page.
There are three probiotic strains in this product for a dosage per capsule of 45 billion CFU:
The other ingredients at the time of this writing (August, 2016) are inulin and xylooligosaccharide (both prebiotics in undisclosed amounts), magnesium stearate, hypromellose and gellan gum.
Please verify ingredients of any supplement prior to taking it.
The manufacturer recommended dosage is 2 – 4 capsules daily with a meal for a minimum of 3 months to realize the full benefits.
I read through the available information so you don’t have to do it. While there are research studies documenting its efficacy, please note that Renadyl is a probiotic supplement and the information presented here is not intended for use as diagnosis, prescription, treatment or cure for any disease. There are several research and observational studies using this probiotic supplement which are summarized below:
In a private veterinary clinic in 2006, 7 cats with elevated BUN and serum creatinine were given this probiotic supplement for 3 months. While not a randomized, blinded, placebo-controlled trial, 100% of cases showed a decrease in BUN ranging from 4.7% to 36.5%, and 6 out of 7 cats showed decreases in creatinine ranging from 10% to 51.9%.
In a small, randomized, double-blind, placebo-controlled crossover study of 22 adults with ESRD on hemodialysis, observed trends of declines in WBC count and reductions in levels of C-reactive protein and total indoxyl glucuronide were noted. These changes did not reach statistical significance. No statistically significant changes were observed in other uremic toxin levels or measures of quality of life based on a modified SF36 questionnaire, although quality of life was said to stabilize. There were two 2-month treatment periods separated by 2-month washout and crossover. Patients were given 2 capsules three times daily with meal of either 30 Billion CFU of the 3 Renadyl probiotics (for a total of 180 billion CFU) or placebo, which consisted interestingly of a 1:1 blend of cream of wheat and psyllium husk. This study suggested that the probiotic supplement is safe to administer to ESRD patients on hemodialysis.
In a prospective, randomized, double-blind, crossover, placebo-controlled, multi-center 6-month trial of this probiotic supplement in 13 patients, significant decreases in BUN occurred during the treatment period. Mean changes in uric acid concentration decrease were moderate during the treatment period and changes in serum creatinine concentration were insignificant. No gastrointestinal nor infectious complications were noted in any patient with improved quality of life.
In a 6-month prospective, randomized, double-blind, placebo-controlled, multi-center crossover trial on 46 patients, 90 billion CFU of this probiotic supplement was well tolerated and safe at all sites. Statistically significant BUN level decreases were experienced in 63% of patients. Non-significant decreases in creatinine in 43% of patients and in uric acid levels in 33% of patients were noted. Eighty six percent of patients expressed a perceived substantial overall improvement in quality of life based on a questionnaire.
In a 2013 open-label dose escalation study, 28 patients in stages 3 and 4 CKD tolerated increasing dosages from 1 capsule of 30 billion CFU three times daily to 3 capsules three times per day (270 billion CFU) and experienced statistically significant changes in serum creatinine, C-reactive protein, hemoglobin and quality of life as measured by physical functioning. The maximum dose was sustained for 2 months. Non-significant decreases in BUN and in pain were also noted.
An article in the International Journal of Medical and Applied Sciences in 2014 summarized responses from 147 survey questionnaires from current (at the time) and former customers of Renadyl. The summary showed over 75% satisfaction of safety, perceived efficacy and performance of the product. The majority was over 50 years of age, retired, in at least stage III of kidney disease, and with at least one or several comorbid conditions. The conclusions from the questionnaires were that the probiotic supplement was safe in all stages of CKD, even with comorbid conditions, and it does not interfere with any other medical treatments, including dialysis. Persons who completed the questionnaire were provided a 25% discount on the next order of the supplement which was deemed an appropriate reward for taking the time to complete the questionnaire.
This supplement may someday be evaluated for prescription drug status. If Kibow pursues this option, there will be many more, and larger, studies performed.
The pros of this probiotic supplement as I see them are:
At the time of this writing (August, 2016) there were 28 positive reviews of this probiotic supplement on the product website. Here is a sample of some of the reviews. Note that GFR is glomerular filtration rate, and it is a calculated indicator of kidney function. A decrease in GFR means worsening of kidney function, whereas an increase means improvement in kidney function. No change in GFR means a stabilization in kidney function. According to the National Kidney Foundation, a GFR over 90 is good, 60-89 should be monitored, and less than 60 for 3 months indicates kidney disease. For more information on GFR, creatinine and chronic kidney disease, see this page.
"My daughter had heard about Renadyl and recommended it to me since my Protein values in my kidneys were too high. However,the biggest problem was that I had to urinate every half hour all night long which became more and more frequent. After taking Renadyl for three(3)weeks I noticed alot of improvement and after six (6) weeks I was back to NORMAL. My kidney Protein values are back to normal as well.
Not a day goes by without taking my Renadyl since it has improved my life tremendously." 5 stars, Ingrid, 6/22/14
"I have Stage 4 kidney failure. Since I started Renadyl, I seem to have more energy and just feel better." 5 stars, Wayne, 12/5/15
"Taking 1-2 capsules of Renadyl a day has kept my GFR stable for 18 months without identifying other variables in my diet or lifestyle." 5 stars, Unknown, 12/22/15
"I’ve been using Renadyl for a little over 6 months now and blood levels are within the normal range (creatine levels are down). Even my skin tone is back normal (used to have a yellowish skin tone).
Other patients have started using it and their comments are nothing but positive. Thanks to Renadyl we’ve been able to have a better quality of life." 5 stars, Yolanda, 1/10/16
"I stared taking Renadyl about eight months ago. Before taking it, my kidney function had been rapidly deteriorating with my blood creatinine increasing to 1.9. Since starting Renadyl, my creatinine level has remained at 1.9, so my CKD has stabilized." 4 stars, Edward, 1/24/16
"my brother who is on dialysis every other day could not even stand on his legs. since he started using Renadyl he is very healthy, walks well, legs look very well in circulatioin and he is enjoying much much better health. he believes he lives on because of the Renadyl when several of his friends at dialysis have already passed." 5 stars, Fr. Philip, 2/15/16
"I have been tested several times a year and my doctor can not accept the fact that Renadyl has kept my kidneys working at the same level for over 4 years." 5 stars, Mike, 3/5/16
"I have been taking Renadyl for two years and my GFR has stayed at 14 (top of end stage). My nephrologist is impressed and says. "Keep doing what you're doiin,, seems to be helping." 5 stars, Unknown, 4/4/16
After taking Renadyl for 2 years my kidney function improved from 50% to 70%." 4 stars, Unknown, 4/12/16
"I have been taken Renadyl faithfully for three months, and I believe it reduce my Micro- albumin, which is use to detect very small levels of a blood protein (albumin) in your urine. A micro-albumin test is used to detect early signs of kidney damage in people who are at risk of developing kidney disease. My micro-albumin creatinine ratio went from 688 down to 271. I contribute Renady to this drop, and my CKD GFR has been stable of three years. I expect my micro-albumin to go lower on my next follow-up." 5 stars, Unknown, 5/18/16
"My Gfer rate went from 24 with threat of dialysis hanging over my head to 34 in seven weeks." 5 stars, Mariellen 6/5/16
"I've been using this product for over 4 years and my doctor can't understand why my kidneys haven't gotten worse." 5 stars, Michael, 6/27/16
"Can't be certain Renadyl alone has kept my GFR stable for two years, but my GFR hasn't decreased in 24 months." 5 stars, Clark 7/26/16
The cons of this probiotic supplement as I see them are:
This supplement is a high potency supplement, has "safe" species of lactic acid bacteria, is free of some allergens, and very importantly, has research in vitro, in animals and in humans to back up its claims for supporting health in chronic kidney disease or end-stage renal disease.
If you would like help in determining if this probiotic supplement is right for you and your CKD, please consider nutritional consultations with me. I can work with your doctor to monitor the effects this supplement will have on your kidney health and help you with dietary and lifestyle considerations.
To read about my approach to supplement reviews, and about my reviews of other probiotic supplements, click here.
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