VSL#3(VSL3): Mega-Probiotic for IBD and IBS. Do you need it?
VSL#3 (AKA "VSL3") is a high-potency probiotic supplement intended for the dietary management of the IBD (inflammatory bowel disease) ulcerative colitis, of an ileal pouch and of IBS (irritable bowel syndrome).
Its trademark description is “The Living Shield”, which I think is very fitting for what probiotics do.
People wonder if it is worth the price, because it can be expensive. Read on because this page can help you decide.
VSL#3 is used by some physicians for Crohn’s disease, but that is technically an “off-label” use (a prescription-drug term). It has been shown in a study to help prevent Crohn's in the early stages in mice, but it is not labeled to help with Crohn's.
It is produced by Sigma-Tau Pharmaceuticals, Inc. and is a
product of the USA.
What Kind of Supplement is VSL3?
VSL#3 is a medical food, meaning:
It is supposed to be used to meet distinctive nutritional requirements of a disease or condition that cannot be met through diet alone
It is supposed to be used only under medical supervision, and
It is intended for the specific dietary management of a disease or condition
Medical foods are NOT drugs.
What Probiotics are in VSL#3?
VSL3 is composed of 8 strains of lactic acid bacteria:
B. breve Y8
B. longum Y10
(recently reclassified as B. lactis)
B. infantis Y1
L. acidophilus MB
L. plantarum MB
L. paracasei MB
What Products Contain VSL#3?
At the time of this writing, VSL3 is available in 5 different products:
Lemon-flavored sachets of powder: 450 billion bacteria per sachet (or packet)
Unflavored sachets of powder: 450 billion bacteria per sachet
Capsules: 112.5 billion bacteria per capsule
Junior watermelon-flavored sachets of powder: 225 billion bacteria per sachet
Prescription-only "DS" powder: 900 billion bacteria per sachet
The powder should be mixed with only cool foods (applesauce, yogurt,
cold soup, etc.) or cool non-carbonated liquids. The capsules may be
opened and the contents mixed with cool foods or cool non-carbonated
How Much is Recommended?
At the time of this writing, the product website for healthcare professionals recommends:
Product IBS Ulcerative Colitis Pouchitis Active UC Capsules 2-4 per day 4-8 per day ----- 8-16 per day Packets ½-1 per day 1-2 per day 2-4 per day 4-8 per day Junior Packets: Depends on the age of the child and the child’s condition
Please note that consumers are supposed to be working with a physician for treatment with these conditions. Follow your doctor’s recommendations as to usage.
When Can You Expect Results?
According to Sigma-Tau Pharmaceuticals, results can be expected within 7 days, but it may take up to one month for the gut to stabilize. Some research has shown that the gut was fully colonized in 20 days. Individual results vary.
What Does the Research Show?
There are advertised to be over 107 scientific studies performed over at least 12 years with this product. Here is a sampling of some of the results in adults:
Studies used from 225 billion cfu/day to 3600 billion cfu/day.
VSL3 can help to repair “leaky gut” to decrease the chances of bacterial translocation, food-particle entrance into circulation and inflammatory immune responses.
It can help in abdominal bloating, reduce gas and slow colonic time in patients with diarrhea-predominant IBS.
It has shown efficacy in ulcerative colitis, with and without drug therapy.
It has shown efficacy in pouchitis.
PROS of VSL#3, In My Opinion
Multiple species, as research shows it takes a village of probiotic organisms to be healthy
Species are proven to inhabit the intestinal tract during usage, and this product supplies the high amounts of bacteria needed to colonize and positively affect the GI tracts of IBS, ulcerative colitis and ileal-pouch patients.
These species do not translocate from the intestines or act opportunistically when given to animals suffering from colitis. Thus, out-of-gut infections with VSL3 are not expected.
Clinically-proven product, as a medical food must be. Instead of just testing each individual strain in laboratory studies and then combining them in a product, VSL3 combines tested strains but also has over 107 scientific studies performed over at least 12 years with it as a whole product.
Live freeze-dried lactic acid bacteria
If stored under refrigeration (36-46°F or 2-8°C), VSL#3 products are guaranteed through the "Best if used by" date, not the manufactured date.
Gluten-free capsules and powders
Kosher and Halal certified
Non-GMO cornstarch in the unflavored powder, and nothing else is GMO in any of their products according to their medical information department.
It is the only probiotic recognized by the American College of Gastroenterology and the German Association of Gastroenterology as an effective tool in the dietary management of pouchitis.
VSL#3 has GRAS (generally recognized as safe under the conditions of their intended use) status in the US.
CONS of VSL#3, In My Opinion
Expensive (but some insurances may cover it)
Daily consumption of high levels of VSL3 is needed to maintain adequate and balanced bacterial colonization. You can't take it sporadically. (But then again, daily consumption of probiotics is a good idea in most cases anyway.)
Not dairy-free. Might contain traces of lactose [less than 0.1g per 100g] and dehydrated skim milk or milk protein (casein and beta-lacto globulin of less than 2mg/Kg).
Definitely requires refrigeration. VSL3 can be stored at room temperature (77°F) for up to one week without having a major effect on potency, but after that or if exposed to high temperatures, the number of beneficial bacteria can become significantly reduced.
Like any probiotic, this one can cause bloating and gas when it is first being used until the body and flora adapt to the changes. Because all the forms of the product are so highly potent, it can be difficult to “ease into” taking VSL#3. You might have to weather some discomfort until your intestines get used to the new environment.
VSL3 is not 100% effective for everybody...But then again, is anything?
Your local pharmacy may carry the non-prescription products. You can also purchase the products from
Amazon.com (which has multiple-package options) or from the VSL#3 website, which also has multiple-package options.
Obviously, the prescription "DS" product is only available with a prescription from your doctor.
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